- 专利标题： Low density lipoprotein receptor-mediated siRNA delivery
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申请号： US13584256申请日： 2012-08-13
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公开(公告)号： US08569258B2公开(公告)日： 2013-10-29
- 发明人: Jon E. Chatterton
- 申请人： Jon E. Chatterton
- 申请人地址： US TX Fort Worth
- 专利权人： Alcon Research, Ltd.
- 当前专利权人： Alcon Research, Ltd.
- 当前专利权人地址： US TX Fort Worth
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/02 ; C07H21/04 ; C07K5/00
摘要：
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.
公开/授权文献
- US20120315288A1 LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED siRNA DELIVERY 公开/授权日：2012-12-13
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