发明授权
- 专利标题： Cytotoxic ribonuclease variants
- 专利标题（中）： 细胞毒性核糖核酸酶变体
-
申请号： US13619192申请日： 2012-09-14
-
公开(公告)号： US08569457B2公开(公告)日： 2013-10-29
- 发明人: Ronald T. Raines , George N. Phillips, Jr. , R. Jeremy Johnson , Jason G. McCoy
- 申请人： Ronald T. Raines , George N. Phillips, Jr. , R. Jeremy Johnson , Jason G. McCoy
- 申请人地址： US WI Madison
- 专利权人： Wisconsin Alumni Research Foundation
- 当前专利权人： Wisconsin Alumni Research Foundation
- 当前专利权人地址： US WI Madison
- 代理机构： Quarles & Brady LLP
- 主分类号： C07K1/00
- IPC分类号： C07K1/00
摘要：
Cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex are disclosed. Also disclosed is the 3-D structure of the hRI·RNase 1 complex and methods for designing the RNase 1 variants.
公开/授权文献
- US20130011904A1 CYTOTOXIC RIBONUCLEASE VARIANTS 公开/授权日：2013-01-10
信息查询
