A liquid crystal display comprising a display region, a control unit, a plurality of source drivers located along a first direction, and a plurality of gate drivers located along a second direction orthogonal to the first direction. A driving method of the liquid crystal display comprises dividing the display region into a plurality of screen regions with each screen region is in correspondence with one source driver or one gate driver; according to the display characteristics of the screen regions. The control unit generates a plurality of regulated signals for changing the output voltage value of the corresponding driver or changing the operating time of the corresponding driver. The regulated signal are sent to the corresponding driver.