Presented are systems and methods that allow for interpolation of a 3-D volume from arbitrarily oriented 2-D medical images. The interpolation of 3-D volume from arbitrarily oriented 2-D images reduces or eliminates most constraints on image acquisition thereby allowing for, inter alia, freehand manipulation of an image acquisition device (e.g. an ultrasound transducer). Related utilities involve the use of prior information about a specific object of interest to interpolate a surface (e.g., 3-D surface) of the object from limited information obtained from very few 2-D images.