Invention Grant
- Patent Title: Antibacterial pharmaceutical composition comprising Aceriphyllum rossii extract and active compounds isolated therefrom
- Patent Title (中): 抗菌药物组合物，其包含槭树提取物和从其中分离的活性化合物
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Application No.: US13129087Application Date: 2008-11-12
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Publication No.: US08574556B2Publication Date: 2013-11-05
- Inventor: Won Gon Kim , Chang Ji Zheng , Ki Young Kim , Mi Jin Sohn
- Applicant: Won Gon Kim , Chang Ji Zheng , Ki Young Kim , Mi Jin Sohn
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon
- Agency: Chalker Flores, LLP
- Agent Chainey P. Singleton; Daniel J. Chalker
- International Application: PCT/KR2008/006654 WO 20081112
- International Announcement: WO2010/055960 WO 20100520
- Main IPC: A61K8/365
- IPC: A61K8/365 ; A61K8/00 ; A61K8/18
Abstract:
The present invention relates to an antibacterial pharmaceutical composition comprising an Aceriphyllum rossii extract, and aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid isolated therefrom. The Aceriphyllum rossii extract of the present invention, and aceriphyllic acid A and 3-oxo-12-oleanen-27-oic acid isolated therefrom have strong antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus, quinolone-resistant S. aureus, Acinetobacter calcoaceticus, Micrococcus luteus, Bacillus subtilis or Streptococcus mutans, Propionibacterium acnes, thereby being used for the prevention or treatment of pathogenic bacterial and resistant bacterial infections, cariogenic bacterial and acne bacterial infections.
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