发明授权
- 专利标题: Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties
- 专利标题(中): 具有非污垢表面的制品及其制备方法,而不改变体积物理性能
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申请号: US13156904申请日: 2011-06-09
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公开(公告)号: US08574660B2公开(公告)日: 2013-11-05
- 发明人: Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
- 申请人: Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
- 申请人地址: US MA Boston
- 专利权人: Semprus Biosciences Corporation
- 当前专利权人: Semprus Biosciences Corporation
- 当前专利权人地址: US MA Boston
- 代理机构: Bryan Cave LLP
- 主分类号: A61L33/00
- IPC分类号: A61L33/00
摘要:
Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.