Invention Grant
- Patent Title: Triazine compounds as PI3 kinase and mTOR inhibitors
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Application No.: US13718928Application Date: 2012-12-18
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Publication No.: US08575159B2Publication Date: 2013-11-05
- Inventor: Aranapakam Mudumbai Venkatesan , Zecheng Chen , Christoph Martin Dehnhardt , Osvaldo Dos Santos , Efren Guillermo Delos Santos , Arie Zask , Jeroen Cunera Verheijen , Joshua Aaron Kaplan , David James Richard , Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Ariamala Gopalsamy , Kevin Joseph Curran , Mengxiao Shi
- Applicant: Pfizer Inc.
- Applicant Address: US NJ Madison
- Assignee: Wyeth LLC
- Current Assignee: Wyeth LLC
- Current Assignee Address: US NJ Madison
- Agent David Rubin
- Main IPC: A61K31/535
- IPC: A61K31/535 ; C07D413/14
Abstract:
Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
Public/Granted literature
- US20130109670A1 TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Public/Granted day:2013-05-02
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