发明授权
US08575375B2 Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
有权
具有强效变构GABA受体氯离子载体调节性质的雄甾烷和孕甾类固醇
- 专利标题： Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
- 专利标题（中）： 具有强效变构GABA受体氯离子载体调节性质的雄甾烷和孕甾类固醇
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申请号： US12664470申请日： 2008-06-16
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公开(公告)号： US08575375B2公开(公告)日： 2013-11-05
- 发明人: Scott P. Runyon , Michael A. Rogawski , Edgar Cook , John Kepler , Hernan Navarro , Rafal Kaminski , Matthew Orr
- 申请人： Scott P. Runyon , Michael A. Rogawski , John Kepler , Hernan Navarro , Rafal Kaminski , Matthew Orr , Kevin M. Cook
- 申请人地址： US NC Research Triangle Park US DC Washington
- 专利权人： Research Triangle Institute,The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： Research Triangle Institute,The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US NC Research Triangle Park US DC Washington
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 国际申请： PCT/US2008/067059 WO 20080616
- 国际公布： WO2008/157460 WO 20081224
- 主分类号： C07J41/00
- IPC分类号： C07J41/00
摘要：
This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
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