发明授权
- 专利标题: Preparation of alpha-hydroxyketones
- 专利标题(中): α-羟基酮的制备
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申请号: US13557281申请日: 2012-07-25
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公开(公告)号: US08575394B2公开(公告)日: 2013-11-05
- 发明人: Nicole End , Reinhard H. Sommerlade , Yvonne Richter
- 申请人: Nicole End , Reinhard H. Sommerlade , Yvonne Richter
- 申请人地址: DE Ludwigshafen
- 专利权人: BASF SE
- 当前专利权人: BASF SE
- 当前专利权人地址: DE Ludwigshafen
- 代理机构: Shruti Costales
- 优先权: EP04103236 20040708
- 主分类号: C07C225/00
- IPC分类号: C07C225/00 ; C07C223/00
摘要:
A process for the preparation of an 1,1-disubstituted oxirane is disclosed, wherein an organic sulphide is reacted in a polar solvent with an educt containing a leaving group attached to a primary or secondary carbon atom, and/or the sulfonium salt formed in this way is reacted with a ketone in presence of a base and a polar solvent. Oxiranes of the type obtained may be further converted into the corresponding α-hydroxyketone or α-aminoketone, either in one step by subjecting to aerobic oxidation in the presence of a transition metal catalyst, or in two steps by hydrolyzation in the presence of an aqueous acid to the corresponding dialcohol and subsequent selective oxidation. Further described are some novel epoxide intermediates. The α-hydroxyketones and α-aminoketones thus obtainable are useful inter alia as photoinitiators.
公开/授权文献
- US20120289721A1 PREPARATION OF ALPHA-HYDROXYKETONES 公开/授权日:2012-11-15