Systems and methods for remote endarterectomy are disclosed. In an embodiment, a device for remote endarterectomy includes an elongated member, having a proximal end, a distal end, and a longitudinal axis therebetween; an endarterectomy unit at the distal end of the elongated member formed by a first member engaged to a second member in a substantial secure alignment with the second member, wherein the endarterectomy unit has a circumferential enclosure configured to separate a plaque core from a blood vessel and an open region surrounded by the enclosure and configured to receive the separated plaque core therethrough; and an actuator coupled to the proximal end of the elongated member for translating the first member relative to the second member across the open space to transect the plaque core received in the open space.