发明授权
- 专利标题： Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders
- 专利标题（中）： 可用于治疗癌症和其他疾病的取代嘧啶衍生物
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申请号： US12158524申请日： 2006-12-20
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公开(公告)号： US08580798B2公开(公告)日： 2013-11-12
- 发明人: Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
- 申请人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
- 申请人地址： DE Monheim
- 专利权人： Bayer Intellectual Property GmbH
- 当前专利权人： Bayer Intellectual Property GmbH
- 当前专利权人地址： DE Monheim
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 国际申请： PCT/US2006/048382 WO 20061220
- 国际公布： WO2007/075650 WO 20070705
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/506
摘要：
Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.