发明授权
US08586750B2 Method for the production of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters
有权
卤素取代的2-(氨基亚甲基)-3-氧代丁酸酯的制备方法
- 专利标题: Method for the production of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters
- 专利标题(中): 卤素取代的2-(氨基亚甲基)-3-氧代丁酸酯的制备方法
-
申请号: US12990364申请日: 2009-04-30
-
公开(公告)号: US08586750B2公开(公告)日: 2013-11-19
- 发明人: Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
- 申请人: Thomas Zierke , Volker Maywald , Michael Rack , Sebastian Peer Smidt , Michael Keil , Bernd Wolf , Christopher Koradin
- 申请人地址: DE Ludwigshafen
- 专利权人: BASF SE
- 当前专利权人: BASF SE
- 当前专利权人地址: DE Ludwigshafen
- 代理机构: Brink Gilson & Lione
- 优先权: EP08155611 20080502
- 国际申请: PCT/EP2009/055285 WO 20090430
- 国际公布: WO2009/133179 WO 20091105
- 主分类号: C07D295/145
- IPC分类号: C07D295/145 ; C07D211/34 ; C07D265/30
摘要:
The present invention relates to a process for preparing 2-(aminomethylidene)-4,4-dihalo-3-oxobutyric esters of the formula (I), wherein R1, R2, R3 are C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C3-C10-cycloalkyl or benzyl, and/or R2 together with R3 and the nitrogen atom to which the two radicals are attached are a heterocyclic radical, in which a corresponding 3-aminoacrylic ester is reacted with a halogen-substituted acetyl fluoride in the presence of at least one alkali or alkaline earth metal fluoride; and the further conversion of halogen-substituted 2-(aminomethylidene)-3-oxobutyric esters of the formula (I) to halomethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.
公开/授权文献
信息查询