发明授权
US08592417B2 2-substituted-6-heterocyclic pyrimidone derivatives as tau protein kinase 1 inhibitors
失效
作为tau蛋白激酶1抑制剂的2-取代-6-杂环嘧啶酮衍生物
- 专利标题： 2-substituted-6-heterocyclic pyrimidone derivatives as tau protein kinase 1 inhibitors
- 专利标题（中）： 作为tau蛋白激酶1抑制剂的2-取代-6-杂环嘧啶酮衍生物
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申请号： US12518997申请日： 2007-12-26
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公开(公告)号： US08592417B2公开(公告)日： 2013-11-26
- 发明人: Kazutoshi Watanabe , Toshiyuki Kohara , Kenji Fukunaga , Fumiaki Uehara
- 申请人： Kazutoshi Watanabe , Toshiyuki Kohara , Kenji Fukunaga , Fumiaki Uehara
- 申请人地址： JP Osaka FR Paris
- 专利权人： Mitsubishi Tanabe Pharma Corporation,Sanofi
- 当前专利权人： Mitsubishi Tanabe Pharma Corporation,Sanofi
- 当前专利权人地址： JP Osaka FR Paris
- 代理机构： Greenblum & Bernstein, P.L.C.
- 优先权： JP2006-357476 20061226
- 国际申请： PCT/JP2007/075380 WO 20071226
- 国际公布： WO2008/078837 WO 20080703
- 主分类号： A61K31/535
- IPC分类号： A61K31/535 ; C07D413/14
摘要：
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein each R1 represents hydrogen atom or the like; X represents oxygen atom or the like; A represents a C3-C7 cycloalkyl group, a C6-C10 aryl group or a heterocyclic group; R6 represents a halogen atom or the like; s represents 0 or an integer of 1 to 5; Q represents a pyridine ring which may be substituted or pyrimidine ring; and R2 represents hydrogen atom or the like, which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of tau protein kinase 1 such as a neurodegenerative diseases (e.g. Alzheimer disease).
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