发明授权
US08592422B2 Bicyclic triazole and pyrazole lactams as allosteric modulators of mGluR5 receptors
失效
双环三唑和吡唑内酰胺作为mGluR5受体的变构调节剂
- 专利标题： Bicyclic triazole and pyrazole lactams as allosteric modulators of mGluR5 receptors
- 专利标题（中）： 双环三唑和吡唑内酰胺作为mGluR5受体的变构调节剂
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申请号： US13329025申请日： 2011-12-16
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公开(公告)号： US08592422B2公开(公告)日： 2013-11-26
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James MacDonald , Han Min Tong , Carrie K. Jones , Manuel Jesús Alcázar-Vaca , José Ignacio Andrés-Gil , Chrysa Malosh
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James MacDonald , Han Min Tong , Carrie K. Jones , Manuel Jesús Alcázar-Vaca , José Ignacio Andrés-Gil , Chrysa Malosh
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 代理机构： Ballard Spahr LLP
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; A61P25/00 ; C07D487/04
摘要：
In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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