发明授权
- 专利标题： Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
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申请号： US13447636申请日： 2012-04-16
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公开(公告)号： US08592441B2公开(公告)日： 2013-11-26
- 发明人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
- 申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人地址： BE Beerse
- 优先权： EP04077172 20040728
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D409/14 ; A61K31/506
摘要：
This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.