Invention Grant
US08598163B2 Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders
失效
[1,3]恶嗪-2-酮的衍生物可用于治疗代谢性疾病如脂质疾病
![Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders](/docs/US/2013-12-03/US08598163B2/abs.jpg.600x600.jpg)
- Patent Title: Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders
- Patent Title (中): [1,3]恶嗪-2-酮的衍生物可用于治疗代谢性疾病如脂质疾病
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Application No.: US13147637Application Date: 2010-02-03
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Publication No.: US08598163B2Publication Date: 2013-12-03
- Inventor: David Claremon , Colin Tice , Suresh Singh , Yuanjie Ye , Katerina Leftheris , Linghang Zhuang
- Applicant: David Claremon , Colin Tice , Suresh Singh , Yuanjie Ye , Katerina Leftheris , Linghang Zhuang
- Applicant Address: US PA Fort Washington DE
- Assignee: Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- Current Assignee: Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- Current Assignee Address: US PA Fort Washington DE
- Agency: McCarter & English LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- International Application: PCT/US2010/023021 WO 20100203
- International Announcement: WO2010/091067 WO 20100812
- Main IPC: A61K31/5355
- IPC: A61K31/5355 ; C07D487/04
![Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders](/abs-image/US/2013/12/03/US08598163B2/abs.jpg.150x150.jpg)
Abstract:
This invention relates to novel compounds of an 11 β-HSD1 inhibitor disclosed herein, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11/3-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Public/Granted literature
- US20120040973A1 DERIVATIVES OF [1,3]OXAZIN-2-ONE USEFUL FOR THE TREATMENT OF METABOLIC DISEASES SUCH AS LIPID DISORDERS Public/Granted day:2012-02-16
Information query
