发明授权
US08598353B2 Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors
失效
苯并唑衍生物，组合物和用作β-分泌酶抑制剂的方法
- 专利标题： Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors
- 专利标题（中）： 苯并唑衍生物，组合物和用作β-分泌酶抑制剂的方法
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申请号： US12950718申请日： 2010-11-19
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公开(公告)号： US08598353B2公开(公告)日： 2013-12-03
- 发明人: Adnan M. M. Mjalli , David R. Jones , Devi Reddy Gohimukkula , Guoxiang Huang , Jeff J. Zhu , Mohan Rao , Robert C. Andrews , Tan Ren
- 申请人： Adnan M. M. Mjalli , David R. Jones , Devi Reddy Gohimukkula , Guoxiang Huang , Jeff J. Zhu , Mohan Rao , Robert C. Andrews , Tan Ren
- 申请人地址： US NC High Point
- 专利权人： High Point Pharmaceuticals, LLC
- 当前专利权人： High Point Pharmaceuticals, LLC
- 当前专利权人地址： US NC High Point
- 代理商 Samuel B. Rollins
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/4725
摘要：
The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
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