This disclosure describes systems and methods for determining a voltage margin (or margin) of a serializer/deserializer (SerDes) receiver in mission mode using a SerDes receiver. This is done by time-division multiplexing a margin determination and a tap weight adaptation onto the same hardware (or software, or combination of hardware and software). In other words, some parts of a SerDes receiver (e.g., an error slicer and an adaptation module) can be used for two different tasks at different times without degrading the effectiveness or bandwidth of the receiver. Hence, the disclosed systems and methods allow a SerDes receiver to determine the SerDes margin in mission mode and without any additional hardware or circuitry on the receiver chip.