发明授权
- 专利标题： Mycobacterial disease detection, treatment, and drug discovery
- 专利标题（中）： 分枝杆菌病检测，治疗和药物发现
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申请号： US12281082申请日： 2007-03-01
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公开(公告)号： US08603751B2公开(公告)日： 2013-12-10
- 发明人: Andries J. C. Steyn , Deborah Mai , Amit Singh
- 申请人： Andries J. C. Steyn , Deborah Mai , Amit Singh
- 申请人地址： US AL Birmingham
- 专利权人： The UAB Research Foundation
- 当前专利权人： The UAB Research Foundation
- 当前专利权人地址： US AL Birmingham
- 代理机构： Kilpatrick, Townsend & Stockton LLP
- 国际申请： PCT/US2007/063099 WO 20070301
- 国际公布： WO2007/101274 WO 20070907
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
Methods for detecting and treating Mycobacterium-related diseases including reducing Mycobacterial virulence, reducing RV3133c dimerization, and treating a subject with a Mycobacterial infection using identified compounds are disclosed. Examples of compounds useful in the treatment of Mycobacterium-related diseases include N-(4-[(acetylamino)sulfonyl]phenyl)-3-phenylpropanamide; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1yl)ethanone hydrochloride; and 1-(1,3-benzoxazol-2-yl)-3-({4-[(2-hydroxyethyl)sulfonyl]phenyl}amino)acrylaldehyde. Further disclosed are methods for identifying agents that interact with a polypeptide in a Mycobacterium cell.
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