Invention Grant
- Patent Title: Compounds for the reduction of beta-amyloid production
- Patent Title (中): 用于减少β-淀粉样蛋白生成的化合物
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Application No.: US13477143Application Date: 2012-05-22
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Publication No.: US08604024B2Publication Date: 2013-12-10
- Inventor: Lorin A. Thompson, III , Jianliang Shi , Yong-Jin Wu , Lawrence R. Marcin , Ramkumar Rajamani , Mendi A. Higgins
- Applicant: Lorin A. Thompson, III , Jianliang Shi , Yong-Jin Wu , Lawrence R. Marcin , Ramkumar Rajamani , Mendi A. Higgins
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent John F. Levis
- Main IPC: C07D279/08
- IPC: C07D279/08 ; C07D513/04 ; C07D417/10

Abstract:
Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: wherein X is selected from the group of CH2, O, and NR2; m=0 or 1; R1 at each instance is selected from the group of halogen, hydroxy, amino, C1-4alkylamino, C1-4dialkylamino, haloC1-4 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; L is a bond, —NHCO—, —NH—, or L and Z together can be absent; Z is a C6-C10-aryl group or a 5-10 membered heterocyclic group which can be further substituted with from 0-3 substituents selected from the group of halogen, haloC1-4 alkoxy, 4-methoxyphenyl, hydroxy, amino, C1-4alkylamino, C1-4dialkylamino, haloC1-4 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; R2 is selected from the group of hydrogen, benzyl, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, acetyl, and methanesulfonyl; and R3, R4 and R5 are independently selected from hydrogen or C1-4alkyl.
Public/Granted literature
- US20130131051A1 COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION Public/Granted day:2013-05-23
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