Invention Grant
US08604196B2 Modulating signal transduction pathways with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-B]pyrazine-6-yl]thiourea
失效
用1-乙基-3- [3-（1-甲基-1H-吡唑-4-基） - 吡啶并[2,3-B]吡嗪-6-基]硫脲调制信号转导途径
![Modulating signal transduction pathways with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-B]pyrazine-6-yl]thiourea](/docs/US/2013-12-10/US08604196B2/abs.jpg.600x600.jpg)
- Patent Title: Modulating signal transduction pathways with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-B]pyrazine-6-yl]thiourea
- Patent Title (中): 用1-乙基-3- [3-（1-甲基-1H-吡唑-4-基） - 吡啶并[2,3-B]吡嗪-6-基]硫脲调制信号转导途径
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Application No.: US13542101Application Date: 2012-07-05
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Publication No.: US08604196B2Publication Date: 2013-12-10
- Inventor: Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
- Applicant: Matthias Gerlach , Irene Seipelt , Eckhard Guenther , Emmanuel Polymeropoulos , Tilmann Schuster , Eckhard Claus
- Applicant Address: DE Frankfurt am Main
- Assignee: Aeterna Zentaris GmbH
- Current Assignee: Aeterna Zentaris GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP07107976 20070510
- Main IPC: C07D495/00
- IPC: C07D495/00
![Modulating signal transduction pathways with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-B]pyrazine-6-yl]thiourea](/abs-image/US/2013/12/10/US08604196B2/abs.jpg.150x150.jpg)
Abstract:
A method of modulating one or more of ras-Raf-Mek-Erk signal transduction pathway, PI3K-Akt signal transduction pathway and SAPK signal transduction pathway with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazine-6-yl]thiourea, its geometric isomer, or its tautomer.
Public/Granted literature
- US20120277219A1 NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF Public/Granted day:2012-11-01
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