A method and data processing system for managing running of instructions in a program. A processor of the data processing system receives a monitoring instruction of a monitoring unit. The processor determines if at least one secondary thread of a set of secondary threads is available for use as an assist thread. The processor selects the at least one secondary thread from the set of secondary threads to become the assist thread in response to a determination that the at least one secondary thread of the set of secondary threads is available for use as an assist thread. The processor changes profiling of running of instructions in the program from the main thread to the assist thread.