发明授权
- 专利标题: Inhibitors of bruton's tyrosine kinase
- 专利标题(中): 布鲁特酪氨酸激酶抑制剂
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申请号: US13358557申请日: 2012-01-26
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公开(公告)号: US08618098B2公开(公告)日: 2013-12-31
- 发明人: Nolan James Dewdney , Rama K. Kondru , Bradley E. Loe , Yan Lou , Joel McIntosh , Timothy D. Owens , Michael Soth
- 申请人: Nolan James Dewdney , Rama K. Kondru , Bradley E. Loe , Yan Lou , Joel McIntosh , Timothy D. Owens , Michael Soth
- 申请人地址: US CA San Francisco
- 专利权人: Roche Palo Alto LLC
- 当前专利权人: Roche Palo Alto LLC
- 当前专利权人地址: US CA San Francisco
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; A61K31/517
摘要:
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-IV: wherein, variables R, X, Y1, Y2, Y2′, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-IV and at least one carrier, diluent or excipient.
公开/授权文献
- US20120129845A1 Inhibitors of Bruton's Tyrosine Kinase 公开/授权日:2012-05-24