发明授权
US08618123B2 Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
有权
苯磺酰基 - 苯并二氢吡喃，二氢苯并噻喃，四氢萘和相关的γ分泌酶抑制剂
- 专利标题： Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
- 专利标题（中）： 苯磺酰基 - 苯并二氢吡喃，二氢苯并噻喃，四氢萘和相关的γ分泌酶抑制剂
-
申请号： US12668550申请日： 2008-07-15
-
公开(公告)号： US08618123B2公开(公告)日： 2013-12-31
- 发明人: Thavalakulamgara K. Sasikumar , Duane A. Burnett , Theodros Asberom , Wen-Lian Wu , Hongmei Li , Ruo Xu , Hubert B. Josien
- 申请人： Thavalakulamgara K. Sasikumar , Duane A. Burnett , Theodros Asberom , Wen-Lian Wu , Hongmei Li , Ruo Xu , Hubert B. Josien
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Susan L. Hess; John C. Todaro
- 国际申请： PCT/US2008/008646 WO 20080715
- 国际公布： WO2009/011851 WO 20090122
- 主分类号： A01N43/42
- IPC分类号： A01N43/42 ; A01N43/18 ; A01N43/16 ; A01N41/10 ; A61K31/44 ; A61K31/38 ; A61K31/35 ; A61K31/10 ; C07D221/18 ; C07D221/22 ; C07D409/00 ; C07D335/04 ; C07D495/00 ; C07D311/78 ; C07D311/94 ; C07C315/00 ; C07C317/00
摘要：
Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L1, n, X, Ar, Y, Z, Q, and Q1 are as defined herein. Also disclosed are methods for inhibiting gamma secretase, methods for treating Alzheimer's disease, methods of treating one or more neurodegenerative diseases, and methods of inhibiting the deposition of amyloid protein (e.g., amyloid beta protein) in, on or around neurological tissue (e.g., the brain) using the compounds of formula 1.0.