Invention Grant
US08618304B2 Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals
有权
酰氨基取代的环状羧酸衍生物及其作为药物的用途
- Patent Title: Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals
- Patent Title (中): 酰氨基取代的环状羧酸衍生物及其作为药物的用途
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Application No.: US13461264Application Date: 2012-05-01
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Publication No.: US08618304B2Publication Date: 2013-12-31
- Inventor: Josef Pernerstorfer , Heinz-Werner Kleemann , Matthias Schaefer , Alena Safarova , Marcel Patek
- Applicant: Josef Pernerstorfer , Heinz-Werner Kleemann , Matthias Schaefer , Alena Safarova , Marcel Patek
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agent Jiang Lin
- Priority: EP09290831 20091102
- Main IPC: C07D401/00
- IPC: C07D401/00 ; A61K31/44
Abstract:
The present invention relates to compounds of the formula I, wherein A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are pharmaceutically active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20120264790A1 ACYLAMINO-SUBSTITUTED CYCLIC CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2012-10-18
Information query
