发明授权
- 专利标题： Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
- 专利标题（中）： 具有水溶性分子内桥的发光染料及其生物偶联物
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申请号： US13181107申请日： 2011-07-12
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公开(公告)号： US08623324B2公开(公告)日： 2014-01-07
- 发明人: Timothy Dubrovsky , Barnaby Abrams , Zhenjun Diwu , Qinglin Meng , Jinfang Liao , Haitao Guo
- 申请人： Timothy Dubrovsky , Barnaby Abrams , Zhenjun Diwu , Qinglin Meng , Jinfang Liao , Haitao Guo
- 申请人地址： US CA Sunnyvale US NJ Franklin Lakes
- 专利权人： AAT Bioquest Inc.,Becton, Dickinson and Company
- 当前专利权人： AAT Bioquest Inc.,Becton, Dickinson and Company
- 当前专利权人地址： US CA Sunnyvale US NJ Franklin Lakes
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Bret E. Field; Glenn J. Foulds
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61M36/14
摘要：
Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crosslinked with a hydrophobic bridge. The invention includes reactive fluorescent dyes, their biological conjugates and uses.
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