发明授权
US08623822B2 KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
有权
KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
- 专利标题： KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
- 专利标题（中）： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
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申请号： US12898119申请日： 2010-10-05
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公开(公告)号： US08623822B2公开(公告)日： 2014-01-07
- 发明人: Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
- 申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
- 申请人地址： CH Manno
- 专利权人： Bracco Suisse SA
- 当前专利权人： Bracco Suisse SA
- 当前专利权人地址： CH Manno
- 代理机构： Pearl Cohen Zedek Latzer Baratz LLP
- 主分类号： C07K14/00
- IPC分类号： C07K14/00
摘要：
The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD