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US08623879B2 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivates and their use as PDE9A modulators 有权
1-杂环基-1,5-二氢 - 吡唑并[3,4-D]嘧啶-4-酮衍生物及其作为PDE9A调节剂的用途

1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivates and their use as PDE9A modulators
摘要：
The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones, Formula (I) with is a mono-, bi- or tri-cyclic heterocyclyl group, the ring members of which are carbon atoms and at least 1, preferably 1, 2 or 3, heteroatom(s), which are selected from the group of nitrogen, oxygen and sulphur, which is in the form of —S(O)r— with r being 0, 1 or 2, and—said heterocyclyl group is or comprises 1 non-aromatic, saturated, or partly unsaturated monocyclic ring which comprises at least 1 heteroatom as ring member and—said heterocyclyl group is bound to the scaffold by said 1 non-aromatic, saturated, or partly unsaturated monocyclic ring which comprises at least 1 heteroatom as ring member. According to one aspect of the invention the new compounds are for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments for the treatment of Alzheimer's disease.
摘要（中）：

本发明涉及新的1,6-二取代的吡唑并嘧啶酮，式（I）是具有单，双或三环杂环基，其环成员是碳原子，并且至少1个，优选1,2或3个 ，选自氮，氧和硫的杂原子，其为-S（O）r-，其中r为0,1或2，并且所述杂环基为或包含1 包含至少1个杂原子作为环成员的非芳族，饱和或部分不饱和单环，并且所述杂环基通过所述1个非芳族，饱和或部分不饱和的单环与支架结合，所述单芳环包括至少1个杂原子 作为环成员。 根据本发明的一个方面，新化合物用于制造药物，特别是用于治疗有关感知，集中，学习或记忆缺陷的病症的药物。 新化合物也用于制备用于治疗阿尔茨海默氏病的药物。

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