发明授权
- 专利标题: Method of preparing sitagliptin and intermediates used therein
- 专利标题(中): 西他列汀及其中使用的中间体的制备方法
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申请号: US13502260申请日: 2010-10-19
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公开(公告)号: US08624026B2公开(公告)日: 2014-01-07
- 发明人: Nam Du Kim , Ji Yeon Chang , Dong Jun Kim , Hyun Seung Lee , Jae Hyuk Jung , Young Kil Chang , Gwan Sun Lee
- 申请人: Nam Du Kim , Ji Yeon Chang , Dong Jun Kim , Hyun Seung Lee , Jae Hyuk Jung , Young Kil Chang , Gwan Sun Lee
- 申请人地址: KR Hwaseong-Si
- 专利权人: Hanmi Science Co., Ltd
- 当前专利权人: Hanmi Science Co., Ltd
- 当前专利权人地址: KR Hwaseong-Si
- 代理机构: Sughrue Mion, PLLC
- 优先权: KR10-2009-0100336 20091021
- 国际申请: PCT/KR2010/007150 WO 20101019
- 国际公布: WO2011/049344 WO 20110428
- 主分类号: C07D487/00
- IPC分类号: C07D487/00
摘要:
Disclosed are a novel, simple and low-cost method for preparing sitagliptin of formula (I), as DPP-IV (dipeptidyl peptidase IV) inhibitor, which is useful in treating type 2 diabetes mellitus and key intermediates used in said preparation of sitagliptin:
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