发明授权
- 专利标题: Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules
- 专利标题(中): 用于小分子同时鉴定和定量的特定内标技术(GSIST)
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申请号: US12990560申请日: 2009-05-01
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公开(公告)号: US08628977B2公开(公告)日: 2014-01-14
- 发明人: Jiri Adamec , Wen-Chu Yang , Fred E. Regnier
- 申请人: Jiri Adamec , Wen-Chu Yang , Fred E. Regnier
- 申请人地址: US IN West Lafayette
- 专利权人: Purdue Research Foundation
- 当前专利权人: Purdue Research Foundation
- 当前专利权人地址: US IN West Lafayette
- 代理机构: Brown Rudnick LLP
- 代理商 Adam M. Schoen
- 国际申请: PCT/US2009/002711 WO 20090501
- 国际公布: WO2009/134439 WO 20091105
- 主分类号: G01N24/00
- IPC分类号: G01N24/00
摘要:
Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distinct forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.
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