发明授权
US08632962B2 PLKS as modifiers of the beta catenin pathway and methods of use
失效
PLKS作为β连环蛋白途径的修饰剂和使用方法
- 专利标题: PLKS as modifiers of the beta catenin pathway and methods of use
- 专利标题(中): PLKS作为β连环蛋白途径的修饰剂和使用方法
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申请号: US10580131申请日: 2004-11-23
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公开(公告)号: US08632962B2公开(公告)日: 2014-01-21
- 发明人: Helen Francis-Lang , Christopher G. Winter , Richard Benn Abegania Ventura , Lynn Margaret Bjerke , Timothy S. Heuer
- 申请人: Helen Francis-Lang , Christopher G. Winter , Richard Benn Abegania Ventura , Lynn Margaret Bjerke , Timothy S. Heuer
- 申请人地址: US CA South San Francisco
- 专利权人: Exelixis, Inc.
- 当前专利权人: Exelixis, Inc.
- 当前专利权人地址: US CA South San Francisco
- 代理机构: McDonnell Boehnen Hulbert & Berghoff LLP
- 国际申请: PCT/US2004/039549 WO 20041123
- 国际公布: WO2005/051319 WO 20050609
- 主分类号: C12Q1/00
- IPC分类号: C12Q1/00 ; C12Q1/68 ; G01N33/53
摘要:
Human PLK genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of PLK are provided.