发明授权
- 专利标题: Heterocycle-substituted piperazino-dihydrothienopyrimidines
- 专利标题(中): 杂环取代的哌嗪子基 - 二氢噻吩并嘧啶
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申请号: US12738429申请日: 2008-10-16
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公开(公告)号: US08637519B2公开(公告)日: 2014-01-28
- 发明人: Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
- 申请人: Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
- 申请人地址: DE Ingelheim am Rhein
- 专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人地址: DE Ingelheim am Rhein
- 代理商 Michael P. Morris; Timothy X. Witkowski
- 优先权: EP07118911 20071019
- 国际申请: PCT/EP2008/063983 WO 20081016
- 国际公布: WO2009/050242 WO 20090423
- 主分类号: C07D495/04
- IPC分类号: C07D495/04 ; A61K31/519 ; A61P11/06 ; A61P25/28 ; A61P25/24 ; A61P25/22 ; A61P25/18 ; A61P35/00
摘要:
Dihydrothienopyrimidinesulphoxides of formula 1 wherein X is SO or SO2, R1 is H or C1-6-alkyl, R2 is H or an organic group as disclosed herein, and R3 is an optionally substituted, mono- or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, mono- or bicyclic heteroaryl, and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions which contain these compounds. These dihydrothienopyrimidinesulphoxides are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system, or cancers.
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