发明授权
- 专利标题: Macrocyclic inhibitors of hepatitis C virus
- 专利标题(中): 丙型肝炎病毒的大环抑制剂
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申请号: US12441812申请日: 2007-11-16
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公开(公告)号: US08637663B2公开(公告)日: 2014-01-28
- 发明人: Pierre Jean-Marie Bernard Raboisson , Herman Augustinus De Kock , David Craig McGowan , Wim Van De Vreken , Lili Hu , Abdellah Tahri , Sandrine Marie Helene Vendeville
- 申请人: Pierre Jean-Marie Bernard Raboisson , Herman Augustinus De Kock , David Craig McGowan , Wim Van De Vreken , Lili Hu , Abdellah Tahri , Sandrine Marie Helene Vendeville
- 申请人地址: IE Little Island Co Cork
- 专利权人: Janssen R&D Ireland
- 当前专利权人: Janssen R&D Ireland
- 当前专利权人地址: IE Little Island Co Cork
- 代理商 Andrea Jo Kamage
- 优先权: EP06124359 20061117
- 国际申请: PCT/EP2007/062436 WO 20071116
- 国际公布: WO2008/059046 WO 20080522
- 主分类号: C07D225/04
- IPC分类号: C07D225/04
摘要:
Inhibitors of HCV replication of formula (I) and the salts and stereoisomers thereof, wherein each dashed line (represented by represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; n is 3, 4, 5, or 6; R4 is C1-6alkyl or C3-7cycloalkyl; R5 is hydrogen, halo, C1-6alkyl, hydroxy, C1-6alkoxy, polyhaloC1-6alkyl; R6 is hydrogen, C1-6alkoxy, mono- or diC1-6alkylamino; or R5 and R6 may form a 5- or 6-membered unsaturated or partially unsaturated ring, optionally comprising one or two selected from O, N and S; R7 is hydrogen; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl; R8 is C3-7cycloalkyl optionally substituted with C1-6alkyl; C1-6alkyl optionally substituted with C3-7cycloalkyl; or —NR8aR8b; R8a and R8b are C1-6alkyl, or both may form a 5- or 6-membered saturated heterocyclic ring; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).
公开/授权文献
- US20100022578A1 MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS 公开/授权日:2010-01-28
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