It is aimed to smoothly perform engagement and disengagement of a fastener of a packaging bag and easily take out an inner content by a desired amount. For these purposes, in a packaging bag 1 with a fastener 20 in which a male fastener element and a female fastener element are attached to inner surfaces of opposing flat surface portions 2a and an opening is opened or closed by engaging or disengaging both the fastener elements, pick-up tabs 40 are provided so as to project outward at a portion corresponding to a mounting portion of the fastener 20, or near the portion. The fastener is formed to be asymmetric with respect to the center thereof so that one side largely protruded is attached so as to be directed inward of the packaging bag.