发明授权
- 专利标题： Molecular probe for imaging of pancreatic islets and use of the same
- 专利标题（中）： 胰岛成像用分子探针及其用途
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申请号： US12872837申请日： 2010-08-31
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公开(公告)号： US08642008B2公开(公告)日： 2014-02-04
- 发明人: Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- 申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Yu Ogawa , Konomu Hirao , Kenji Nagakawa , Hirokazu Matsuda
- 申请人地址： JP Kyoto JP Kyoto
- 专利权人： Kyoto University,ARKRAY, Inc.
- 当前专利权人： Kyoto University,ARKRAY, Inc.
- 当前专利权人地址： JP Kyoto JP Kyoto
- 代理机构： Morgan, Lewis & Bockius LLP
- 优先权： JP2009-204769 20090904; WOPCT/JP2010/054450 20100316
- 主分类号： A61K51/08
- IPC分类号： A61K51/08
摘要：
To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides: Z-DLSXQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (1) Z-DLSKQMEEEAVRLFIEWLXNGGPSSGAPPPS-NH2 (5) B-DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (9) where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring, wherein A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, R1 represents a substituent that contains radioactive iodine, R2 represents either a hydrogen atom or a substituent different from that represented by R1, and R3 represents any one of a bond, a methylene group, and an oxymethylene group.
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