发明授权
US08642031B2 Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof
有权
BMP9，BMP10，ALK1和其他ALK1配体的拮抗剂及其用途
- 专利标题： Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof
- 专利标题（中）： BMP9，BMP10，ALK1和其他ALK1配体的拮抗剂及其用途
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申请号： US12467170申请日： 2009-05-15
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公开(公告)号： US08642031B2公开(公告)日： 2014-02-04
- 发明人: Jasbir Seehra , John Knopf , Robert S. Pearsall , Asya Grinberg , Ravindra Kumar
- 申请人： Jasbir Seehra , John Knopf , Robert S. Pearsall , Asya Grinberg , Ravindra Kumar
- 申请人地址： US MA Cambridge
- 专利权人： Acceleron Pharma, Inc.
- 当前专利权人： Acceleron Pharma, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.
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