发明授权
- 专利标题： 1-phenylpyrrole derivatives
- 专利标题（中）： 1-苯基吡咯衍生物
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申请号： US13122239申请日： 2009-10-07
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公开(公告)号： US08642640B2公开(公告)日： 2014-02-04
- 发明人: John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Hiroyuki Tsuruoka , Kazumasa Aoki , Masatoshi Honzumi , Yusuke Asoh , Keiji Saito , Tsuyoshi Homma
- 申请人： John Nuss , Matthew Williams , Raju Mohan , Richard Martin , Tie-Lin Wang , Hiroyuki Tsuruoka , Kazumasa Aoki , Masatoshi Honzumi , Yusuke Asoh , Keiji Saito , Tsuyoshi Homma
- 申请人地址： US CA South San Francisco JP Tokyo
- 专利权人： Exelixis, Inc.,Daiichi Sankyo Company, Limited
- 当前专利权人： Exelixis, Inc.,Daiichi Sankyo Company, Limited
- 当前专利权人地址： US CA South San Francisco JP Tokyo
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 国际申请： PCT/US2009/059852 WO 20091007
- 国际公布： WO2010/042626 WO 20100415
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; C07D207/08
摘要：
The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases, nephropathy, fibrosis, primary aldosteronism or edema. The compound is of the following general formula (I): wherein R1 represents a C1-C3 alkyl group; R2 represents a hydroxy-C1-C4 alkyl group and the like; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like, —R5 represents a sulfamoyl group or a C1-C3 alkylsulfonyl group; R6 represents a hydrogen atom, a halogeno group and the like] or an N-oxide, atropisomer of the foregoing, or pharmaceutically acceptable salt of the foregoing.
公开/授权文献
- US20110263544A1 1-Phenylpyrrole Derivatives 公开/授权日：2011-10-27
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