The claimed subject matter provides systems and/or methods that facilitate combining analog and digital gain for utilization with CMOS sensor imagers. The analog gain can provide coarse gain steps and the digital gain can provide finer gain steps between adjacent coarse analog gain values. Further, since analog gain can suffer from low precision, dispersion, etc., on-chip calibration can be implemented to calibrate the analog and digital gain. For example, a digital amplifier can be calibrated to compensate for differences between actual and nominal analog gains associated with one or more analog amplifiers.