发明授权
US08648085B2 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders
有权
1,5-二氢 - 吡唑并(3,4-D)嘧啶-4-酮衍生物及其用作治疗CNS紊乱的PDE9A混悬剂
- 专利标题: 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders
- 专利标题(中): 1,5-二氢 - 吡唑并(3,4-D)嘧啶-4-酮衍生物及其用作治疗CNS紊乱的PDE9A混悬剂
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申请号: US12744750申请日: 2008-11-27
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公开(公告)号: US08648085B2公开(公告)日: 2014-02-11
- 发明人: Christian Eickmeier , Cornelia Dorner-Ciossek , Dennis Fiegen , Thomas Fox , Klaus Fuchs , Riccardo Giovannini , Niklas Heine , Martin Hendrix , Holger Rosenbrock , Gerhard Schaenzle
- 申请人: Christian Eickmeier , Cornelia Dorner-Ciossek , Dennis Fiegen , Thomas Fox , Klaus Fuchs , Riccardo Giovannini , Niklas Heine , Martin Hendrix , Holger Rosenbrock , Gerhard Schaenzle
- 申请人地址: DE Ingelheim am Rhein
- 专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人地址: DE Ingelheim am Rhein
- 代理商 Michael P. Morris; Edward S. Lazer
- 优先权: EP07425764 20071130; EP08163548 20080903; EP08169282 20081117
- 国际申请: PCT/EP2008/066350 WO 20081127
- 国际公布: WO2009/068617 WO 20090604
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/519 ; A61P25/28 ; A61P3/04 ; A61P3/10 ; A61P25/16
摘要:
The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterized by general Formula (I): with R1 being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1 to 3 substituents X; X independently of each other being selected from C2-C6-alky1 or Ci-C6-alkoxy, where C2-C6-alkyl and C1-C6-alkoxy are at least dihalogenated up to perhalogenated. preferably with 2 to 6 halogen substituents, and the halogen atoms being selected from the group of fluoro, chloro and bromo, preferably fluoro; R2 being phenyl or heteroaryl, where phenyl is substituted by 1 to 3 radicals and heteroaryl is optionally substituted by 1 to 3 radicals in each case independently of one another selected from the group of C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, cyano, trifluoromethyl, amino, nitro, hydroxy, C1-C6-alkylamino, halogen, C6-C10-arylcarbonylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl. C1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl. heteroarylcarbonylamino, C1-C6-alkylsulphonyl-amino, C1-C6-alkylsulphonyl and C1-C6-alkylthio; The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving, perception, concentration, learning and/or memory in patients in need thereof.