发明授权
US08648116B2 Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same
有权
包括作为MEK抑制剂的多晶型物的N-（芳基氨基）磺酰胺的衍生物以及组合物，使用方法及其制备方法
- 专利标题： Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same
- 专利标题（中）： 包括作为MEK抑制剂的多晶型物的N-（芳基氨基）磺酰胺的衍生物以及组合物，使用方法及其制备方法
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申请号： US12671287申请日： 2008-07-28
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公开(公告)号： US08648116B2公开(公告)日： 2014-02-11
- 发明人: Jean-Michel Vernier , Colin Edward Rowlings , Jean-Luc Girardet , Stuart Dimock , Barry Quart , Jeffrey N. Miner
- 申请人： Jean-Michel Vernier , Colin Edward Rowlings , Jean-Luc Girardet , Stuart Dimock , Barry Quart , Jeffrey N. Miner
- 申请人地址： US CA San Diego
- 专利权人： Ardea Biosciences, Inc.
- 当前专利权人： Ardea Biosciences, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 国际申请： PCT/US2008/071392 WO 20080728
- 国际公布： WO2009/018233 WO 20090205
- 主分类号： A61K31/185
- IPC分类号： A61K31/185 ; C07C311/00
摘要：
This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative diseases and inflammatory conditions. The invention also concerns methods of making the compounds and compositions described herein.