Invention Grant
- Patent Title: Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis
- Patent Title (中): 酶促核酸合成：抑制焦磷酸分解的组合物和方法
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Application No.: US13644469Application Date: 2012-10-04
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Publication No.: US08648179B2Publication Date: 2014-02-11
- Inventor: Susan H. Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
- Applicant: Life Technologies Corporation
- Applicant Address: US CA Carlsbad
- Assignee: Life Technologies Corporation
- Current Assignee: Life Technologies Corporation
- Current Assignee Address: US CA Carlsbad
- Main IPC: C07G3/00
- IPC: C07G3/00 ; C12Q1/68 ; C12P19/34
Abstract:
Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
Public/Granted literature
- US20130102050A1 ENZYMATIC NUCLEIC ACID SYNTHESIS: COMPOSITIONS AND METHODS FOR INHIBITING PYROPHOSPHOROLYSIS Public/Granted day:2013-04-25
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