发明授权
US08653281B2 Process for the manufacture of agomelatine and its intermediate
有权
制备agomelatine及其中间体的方法
- 专利标题： Process for the manufacture of agomelatine and its intermediate
- 专利标题（中）： 制备agomelatine及其中间体的方法
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申请号： US13056032申请日： 2009-07-23
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公开(公告)号： US08653281B2公开(公告)日： 2014-02-18
- 发明人: Guisen Zhang , Daopeng Chen , Yanqin Ma , Xiangping Yang , Shixia Zhou , Liang Chen
- 申请人： Guisen Zhang , Daopeng Chen , Yanqin Ma , Xiangping Yang , Shixia Zhou , Liang Chen
- 申请人地址： CN
- 专利权人： NHWA Pharma. Corporation
- 当前专利权人： NHWA Pharma. Corporation
- 当前专利权人地址： CN
- 代理机构： Myers Bigel Sibley & Sajovec, P.A.
- 优先权： CN200810020827 20080729
- 国际申请： PCT/CN2009/072886 WO 20090723
- 国际公布： WO2010/012208 WO 20100204
- 主分类号： C07D209/48
- IPC分类号： C07D209/48
摘要：
A process for the manufacture of agomelatine and its intermediate N-[2-(7-methoxy- 1-naphthy)ethyl]phthalimide is provided and inclues reacting 7-methoxy-1-naphthyl ethanol (III) with benzenesulfonyl chloride to obtain 7-methoxy-1 -naphthylethyl benzene sulfonate (IV), which is reacted with potassium phthalimide to produce N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II); and subjecting N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II) to alkaline hydrolysis and acetylation, to obtain agomelatine.
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