Incoming data at a high-speed serial receiver is digitized and then digital signal processing (DSP) techniques may be used to perform digital equalization. Such digital techniques may be used to correct various data anomalies. In particular, in a multi-channel system, where crosstalk may be of concern, knowledge of the characteristics of the other channels, or even the data on those channels, may allow crosstalk to be subtracted out. Knowledge of data channel geometries, particularly in the context of backplane transmissions, may allow echoes and reflections caused by connectors to be subtracted out. As data rates increase, fractional rate processing can be employed. For example, the analog-to-digital conversion can be performed at half-rate and then two DSPs can be used in parallel to maintain throughput at the higher initial clock rate. At even higher rates, quadrature techniques can allow analog-to-digital conversion at quarter-rate, with four DSPs used in parallel.