发明授权
- 专利标题： Humanized anti-TNFα antibodies
- 专利标题（中）： 人源化抗TNFα抗体
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申请号： US13405144申请日： 2012-02-24
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公开(公告)号： US08658171B2公开(公告)日： 2014-02-25
- 发明人: Baoguo Zhu , Desheng Tao , Bill Nai-Chau Sun , Lee-Hwei King Sun , Ruey Shyan Liou , Cecily Rou-Yun Sun , Qiang Li , Yucai Peng , Jingwei Zhang , Zhenxiang Hu
- 申请人： Baoguo Zhu , Desheng Tao , Bill Nai-Chau Sun , Lee-Hwei King Sun , Ruey Shyan Liou , Cecily Rou-Yun Sun , Qiang Li , Yucai Peng , Jingwei Zhang , Zhenxiang Hu
- 申请人地址： CN Zhuhai, Guangdong
- 专利权人： Livzon Mabpharm Inc.
- 当前专利权人： Livzon Mabpharm Inc.
- 当前专利权人地址： CN Zhuhai, Guangdong
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner LLP.
- 优先权： CN201110048505 20110228; CN201210026698 20120207; WOPCT/CN2012/071079 20120213
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved.
公开/授权文献
- US20120219547A1 Humanized Anti-TNFalpha Antibodies 公开/授权日：2012-08-30