发明授权
- 专利标题： Small molecule potentiators of metabotropic glutamate receptors I
- 专利标题（中）： 代谢型谷氨酸受体的小分子增效剂I
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申请号： US13071753申请日： 2011-03-25
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公开(公告)号： US08664214B2公开(公告)日： 2014-03-04
- 发明人: Wilfried Braje , Katja Jantos , Hervé Geneste , Mario Mezler , Margaretha Henrica Maria Bakker , Jayne Froggett
- 申请人： Wilfried Braje , Katja Jantos , Hervé Geneste , Mario Mezler , Margaretha Henrica Maria Bakker , Jayne Froggett
- 申请人地址： DE Wiesbaden
- 专利权人： AbbVie Deutschland GmbH & Co. KG
- 当前专利权人： AbbVie Deutschland GmbH & Co. KG
- 当前专利权人地址： DE Wiesbaden
- 代理机构： Michael Best & Friedrich LLP
- 代理商 Lisa V. Mueller
- 主分类号： C07D231/12
- IPC分类号： C07D231/12 ; C07D409/04 ; A61K31/4164
摘要：
The present invention relates to small molecule potentiators of metabotropic receptors, in particular of the mGlu2 receptor. The present invention also relates to the use of these compounds for the prevention or treatment of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The present invention thus provides compounds of formula I and variables defined herein.
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