发明授权
US08664216B2 Spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes
有权
螺-5,6-二氢-4H-2,3,5,10b-四氮杂 - 苯并[e]薁
- 专利标题: Spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes
- 专利标题(中): 螺-5,6-二氢-4H-2,3,5,10b-四氮杂 - 苯并[e]薁
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申请号: US12613554申请日: 2009-11-06
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公开(公告)号: US08664216B2公开(公告)日: 2014-03-04
- 发明人: Caterina Bissantz , Erwin Goetschi , Roland Jakob-Roetne , Raffaello Masciadri , Emmanuel Pinard , Hasane Ratni , Mark Rogers-Evans , Patrick Schnider
- 申请人: Caterina Bissantz , Erwin Goetschi , Roland Jakob-Roetne , Raffaello Masciadri , Emmanuel Pinard , Hasane Ratni , Mark Rogers-Evans , Patrick Schnider
- 申请人地址: US NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 优先权: EP08169028 20081113
- 主分类号: A61P9/00
- IPC分类号: A61P9/00 ; A61K31/55 ; C07D487/12
摘要:
The present invention is concerned with spiro-dihydrotetraazabenzoazulenes, i.e. spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes of formula I wherein R1, R2, R3, X, Y, Z, m and n are as described herein. The compounds according to the invention act as V1a receptor modulators and are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.
公开/授权文献
- US20100120751A1 SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENES 公开/授权日:2010-05-13
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