Invention Grant
US08664226B2 Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same
失效
具有3-杂芳基嘧啶-4-(3H) - 酮结构的化合物和含有它们的药物制剂
- Patent Title: Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same
- Patent Title (中): 具有3-杂芳基嘧啶-4-(3H) - 酮结构的化合物和含有它们的药物制剂
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Application No.: US13263023Application Date: 2010-04-16
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Publication No.: US08664226B2Publication Date: 2014-03-04
- Inventor: Toru Miura , Kazuhiro Onogi , Seiichi Sato , Junya Tagashira , Gen Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
- Applicant: Toru Miura , Kazuhiro Onogi , Seiichi Sato , Junya Tagashira , Gen Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
- Applicant Address: JP Nagoya-shi, Aichi
- Assignee: Kowa Company, Ltd.
- Current Assignee: Kowa Company, Ltd.
- Current Assignee Address: JP Nagoya-shi, Aichi
- Agency: Westerman, Hattori, Daniels & Adrian, LLP
- Priority: JP2009-101347 20090417
- International Application: PCT/JP2010/002766 WO 20100416
- International Announcement: WO2010/119700 WO 20101021
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/506

Abstract:
Disclosed is a compound which has both an angiotensin-II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, renal diseases, arteriosclerosis, inflammatory diseases, type-2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. [In the formula, A represents a 5- to 10-membered heteroaryl group; R1 and R2 independently represent a C1-6 alkyl group; and each of R3 to R5 is absent or represents H, a halogen atom, OH, NO2, a halo-C1-6 alkyl group, a (substituted) C1-6 alkoxy group, a (substituted) C3-6 cycloalkyloxy group, or a 5- to 10-membered heteroaryl group.]
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