Invention Grant
US08664390B2 Process for the introduction of hydroxyethoxy side chain in bosentan
有权
在波生坦中引入羟基乙氧基侧链的方法
- Patent Title: Process for the introduction of hydroxyethoxy side chain in bosentan
- Patent Title (中): 在波生坦中引入羟基乙氧基侧链的方法
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Application No.: US12665997Application Date: 2008-06-27
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Publication No.: US08664390B2Publication Date: 2014-03-04
- Inventor: Abhay Gaitonde , Bindu Manojkumar , Sandeep Sonawane , Dattatrey Kokane , Sandeep Mekde , Dattatraya Shinde , Prakash Bansode
- Applicant: Abhay Gaitonde , Bindu Manojkumar , Sandeep Sonawane , Dattatrey Kokane , Sandeep Mekde , Dattatraya Shinde , Prakash Bansode
- Applicant Address: GB Hertfordshire
- Assignee: Generics (UK) Limited
- Current Assignee: Generics (UK) Limited
- Current Assignee Address: GB Hertfordshire
- Agency: Fulbright & Jaworski L.L.P.
- Agent Scott D. Rothenberger
- Priority: IN1245/MUM/2007 20070629
- International Application: PCT/GB2008/050517 WO 20080627
- International Announcement: WO2009/004374 WO 20090108
- Main IPC: C07D403/04
- IPC: C07D403/04 ; A61K31/505
Abstract:
The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.
Public/Granted literature
- US20100249162A1 PROCESS FOR THE INTRODUCTION OF HYDROXYETHOXY SIDE CHAIN IN BOSENTAN Public/Granted day:2010-09-30
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