发明授权
- 专利标题： Highly functional enzyme having α-galactosidase activity
- 专利标题（中）： 具有α-半乳糖苷酶活性的高功能酶
-
申请号： US13667294申请日： 2012-11-02
-
公开(公告)号： US08668907B2公开(公告)日： 2014-03-11
- 发明人: Hitoshi Sakuraba , Youichi Tajima , Mai Ito , Seiichi Aikawa , Fumiko Aikawa
- 申请人： Tokyo Metropolitan Organization for Medical Science , Altif Laboratories
- 申请人地址： JP Setagaya-Ku, Tokyo JP Tokyo
- 专利权人： Tokyo Metropolitan Institute of Medical Science,Altif Laboratories
- 当前专利权人： Tokyo Metropolitan Institute of Medical Science,Altif Laboratories
- 当前专利权人地址： JP Setagaya-Ku, Tokyo JP Tokyo
- 代理机构： Westerman, Hattori, Daniels & Adrian, LLP
- 优先权： JP2005-333660 20051118
- 主分类号： A61K38/43
- IPC分类号： A61K38/43 ; A61K38/47 ; C12N9/40 ; C12P21/06 ; C07H21/04 ; C07K1/00
摘要：
The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired α-galactosidase activity by changing the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
公开/授权文献
信息查询
IPC分类:
