A method and apparatus for providing uplink macro-diversity in packet-switched networks that allows packets and/or portions of packets, e.g., frames, to be selectively sent from an end node, e.g., wireless communication device or mobile terminal, over a set of multiple communication connections, e.g., physical-layer or link-layer connections, to one or more access nodes, e.g., base stations. Uplink macro-diversity is achieved in part through intelligent selective forwarding over multiple communication connections, where the forwarding decision is controlled by the end node based on a variety of factors, e.g., physical-layer channel conditions and/or higher layer policy. The forwarding decision is executed on a rapid timescale, e.g., on a per packet basis, to adapt to the dynamically varying conditions of the set of communication connections.